Targeting Notch in Cancer PDF
By:Lucio Miele,Spyros Artavanis-Tsakonas
Published on 2018-11-23 by Springer
The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected
This Book was ranked at 27 by Google Books for keyword biology abbreviation.
Book ID of Targeting Notch in Cancer's Books is EZl7DwAAQBAJ, Book which was written byLucio Miele,Spyros Artavanis-Tsakonashave ETAG "AV51/93kRwc"
Book which was published by Springer since 2018-11-23 have ISBNs, ISBN 13 Code is 9781493988594 and ISBN 10 Code is 149398859X
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