Biological DNA Sensor PDF
By:Rebecca Schmidt,Laurel L. Lenz
Published on 2013-10-30 by Elsevier Inc. Chapters
Cyclic dinucleotides (c-di-NMPs), such as c-di-GMP and c-di-AMP were first discovered in bacteria, where they play important roles as second messenger molecules that regulate bacterial cellular functions. In addition, these and other c-di-NMPs exert potent biological effects on mammalian cells, such as the inhibition of cancer cell proliferation, immune cell activation, and the triggering of type I interferon production. Here, we introduce the biology of c-di-NMPs in bacterial systems and review the current state of the literature on their biological effects in mammalian cells. Emphasis is placed on evaluating the evidence that c-di-NMPs have potent immune stimulatory effects on cultured mouse and human cells and can act as adjuvants and immune stimulants in animal models. In addition, we highlight areas where further experimentation could hasten the development of c-di-NMPs as adjuvants in potent and safe systemic and mucosal vaccines.
This Book was ranked at 26 by Google Books for keyword biology about dna.
Book ID of Biological DNA Sensor's Books is VD11DAAAQBAJ, Book which was written byRebecca Schmidt,Laurel L. Lenzhave ETAG "TXpCmqKsH8o"
Book which was published by Elsevier Inc. Chapters since 2013-10-30 have ISBNs, ISBN 13 Code is 9780128068861 and ISBN 10 Code is 0128068868
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