The Polymerase Chain Reaction PDF
By:Kary B. Mullis,Francois Ferre,Richard A. Gibbs
Published on 2012-02-02 by Springer Science & Business Media
James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. |It has not escaped our notice,| Francis wrote, |that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material.| By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act |. . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before| and, moreover, | ...
This Book was ranked at 2 by Google Books for keyword biology about dna.
Book ID of The Polymerase Chain Reaction's Books is gjrTBwAAQBAJ, Book which was written byKary B. Mullis,Francois Ferre,Richard A. Gibbshave ETAG "wG0fRrEyH/k"
Book which was published by Springer Science & Business Media since 2012-02-02 have ISBNs, ISBN 13 Code is 9781461202578 and ISBN 10 Code is 1461202574
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